Paula Rodriguez Miguelez, PhDKinesiology and Health Sciences
The Vascular and Integrative Physiology Laboratory
My primary research interests are focused on understanding the physiological and molecular mechanisms that contribute to the development of vascular dysfunction and exercise intolerance in different populations.
The impact of early life stress in cardiovascular health Adverse childhood experiences (ACEs), including abuse, neglect, or severe household dysfunctions, are traumatic experiences during the first years of life directly linked to the development of multiple conditions during adulthood. Recent data suggest that stress early in life may contribute to a premature development of cardiovascular diseases, however the mechanisms are still unknown. Thus, the goal of this line of research is to understand the relationship between adversity during childhood and cardiovascular health.
Exercise intolerance in Cystic Fibrosis Exercise intolerance, defined as an impairment in the capacity to perform physical activities, is a frequent complaint of people with Cystic Fibrosis (CF). A common assumption is that pulmonary dysfunction is the main factor contributing to excessive fatigue in this population. Recent data support that muscle and vascular dysfunctions may play an important role in the development of exercise intolerance in CF, although the exact mechanisms are still unknown. Thus, the goal of this line of research is to understand the molecular and physiological mechanisms that are involved in the development of exercise intolerance in cystic fibrosis.
Emergency care/intensive care/cardiac/pulmonary, Personalized Translational Medicine
